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GLP-1s primarily work by promoting insulin secretion and suppressing appetite, while MOTS-c works at a more fundamental cellular level by enhancing insulin sensitivity and energy expenditure

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Semaglutide: Proven effective in multiple large-scale randomized controlled trials (RCTs) , including the PIONEER and SUSTAIN programs Reduces body weight and improves cardiovascular risk factors Demonstrates efficacy across diverse populations and geographies Supported by meta-analyses and real-world studies AOD9604: Limited human trial data Mixed results in weight loss outcomes Primarily experimental, with no regulatory approval Lack of large, well-controlled studies limits clinical confidence Safety and Side Effects Semaglutide Semaglutides safety profile is well-documented