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Funding This research was supported by Islamic Azad University, Rasht Branch

145 Diagnostic approaches include the Quantitative Sudomotor Axon Reflex Test, Electrochemical Skin Conductance (ESC) using devices like Sudoscan, and the Neuropad Test

Those on the HFD received daily gavage administration of CB-839 (200 mg kg 1 body weight) or vehicle for 19 days (25% (w/v) hydroxypropyl--cyclodextrin (ThermoFisher) in 10 mmol l 1 citrate buffer (pH 2)), while the standard chow group received vehicle only

The primary objective is to determine safety and tolerability for the combination treatment of erdafitinib with targeted treatments