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Long-term safety of lenalidomide (LEN) in relapsed/refractory multiple myeloma (RRMM) patients (Pts): Analysis of pooled data

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Alterations in these genes result in shortening of telomeres, which in turn leads to defects in proliferation and spontaneous chromosomal rearrangements.[199] Levels of TERC, the RNA component of the telomerase complex, are reduced in all dyskeratosis congenita patients.[200] Missense pathogenic variants in WRAP53 , a gene with a protein product that facilitates trafficking of telomerase, have also been associated with an autosomal recessive form of dyskeratosis congenita.[201] Pathogenic variants in C16orf57 were identified in 6 of 132 families who did not have a variant detected in other known genes.[202] C16orf57 pathogenic variants are also associated with poikiloderma with neutropenia.[203] For more information about poikiloderma congenitale, see the Rothmund-Thomson syndrome section

Ozempic face and Ozempic butt are colloquial terms describing the facial sagging and loss of buttock fullness some people experience after significant weight loss with medications like Ozempic