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Description
Nrf2 is inhibited by Kelch-like ECH-associated protein 1 (Keap1): specifically, it increases Nrf2 proteasome-mediated degradation [20,21]
For this reason, and its association with both stomach as well as lung cancer, it is designated an IARC group I carcinogen [98]
For instance, Recouvreux et al
Acquired B12 deficiency and inborn errors in its metabolism are recognized causes of CNS demyelination, so its deficiency in MS would be expected to contribute to progression
