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Under the heat shock condition of 42 C, this acetylation modification enhances the activation efficiency of the HSP70 promoter, and accelerates the transcription of stress-related genes through the recruitment of the chromatin remodeling complex SWI/SNF.GCN5L-mediated acetylation of HSP70 enhances its stability and function, helping cells protect vital organelles and proteins under high-temperature conditions (Strange et al., 2018)
AMPK in intestinal health and disease: a multifaceted therapeutic target for metabolic and inflammatory disorders
