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PMID: 26277634 9 Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study
But the mechanism is on solid ground, and practitioners already running this combination in their practice are reporting the kind of results you would expect from the biology

Four weeks of weekly doses at 2.5mg fits perfectly within that window

Regular exercise improves joint flexibility and mood, while stress reduction practices like meditation can calm the immune system
