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Description
Treatment of depression in cardiovascular disease
The tripeptide-copper complex demonstrates dual MMP regulation: inhibiting MMP-1 and MMP-2 while selectively stimulating MMP-9, supporting balanced extracellular matrix remodeling
The McCoy 2013 paper extended this work by introducing N- and C-terminal modifications designed to enhance metabolic stability and hydrophobicity, ultimately producing Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) as an orally active, BBB-permeable analog [2]
Tyrosinase is the key enzyme that initiates the melanogenesis biosynthesis pathway [14]
