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Common activation mechanism of class A GPCRs
Polymorphisms in genes that encode key antioxidant enzymes, such as SOD2 Val16Ala, can influence enzyme activity and are associated with differential responses to oxidative stress and exercise training [191]

doi: 10.1006/bbrc.1994.2378, 42

It emphasizes the importance of complex clinical, biochemical, radiologic and even genetic evaluation to identify the true cause of osteoporosis in young patients with multiple low-trauma fractures
