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The addition of glucagon receptor activation introduces direct thermogenic and lipolytic effects that neither GLP-1 nor GIP agonism provides alone, creating a mechanism that, in some ways, bridges the gap between the direct fat-targeting approach of AOD 9604 and the systemic metabolic reprogramming of tirzepatide

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Monitoring: Clinical response assessment rather than routine serum B12 measurement, as levels remain elevated following injection regardless of tissue adequacy

AOD9604 might also be combined with metabolic compounds like MOTS-c to study whether enhanced mitochondrial function and direct lipolysis work additively