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The condition involves dysregulation of neurotransmitters, inflammatory mediators, and stress response systems, producing a constellation of symptoms extending far beyond pain to include crushing fatigue, unrefreshing sleep, cognitive dysfunction known as fibro fog, and heightened sensitivity to temperature, sound, and light

the principal pharmacological-interaction consideration is co-administration with exogenous melatonin or other pineal-axis-modifying agents, where the proposed mechanism overlaps and pharmacodynamic addition rather than subtraction would be expected

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