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A factor involved in breast tumour resistance to therapy over expression of the P-glycoprotein transporter, also appears to be present in human lung adenocarcinoma cell lines [216]
Those with borderline hypertension should monitor regularly during PT-141 use
The arginine accumulation within tumor cells can activate mTORC1 signal transduction and aid in tumor growth and metabolic adaptation, while aspartic acid can participate in tumor cell nucleotide synthesis and TCA cycle (Tajan et al., 2018
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