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This includes the use of advanced analytical techniques (e.g., liquid chromatography-mass spectrometry) to quantify TCM components and their metabolites in plasma, gut, and liver tissues, as well as the integration of pharmacokinetic and pharmacodynamic data to establish doseresponse relationships

Clinically, ALS presents itself as a progressive ascending paralysis and muscle atrophy leading ultimately to respiratory failure and death

N-methylated glutathione analogues demonstrate a 16.1-fold increase in oral bioavailability compared to native GSH

it inhibits microglial activation and has been shown to reduce serum levels of inflammatory cytokines in toxininduced parkinsonian rats [43, 44]