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1 Introduction Heart failure with preserved left ventricular ejection fraction (HFpEF) is a systemic multi-organ disease that often coexists with chronic metabolic conditions such as obesity, diabetes, and hyperlipidemia (Joseph et al., 2020

This is because lipid body content is an important contributory factor towards healthy oocyte and embryo development and therefore its alteration may lead to infertility [37]

Serum CK levels should be measured at baseline and periodically during treatment or as clinically indicated with occurrence of musculoskeletal AEs [13, 20]

Rapid LC-MRM-MS assay for simultaneous quantification of choline, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in human plasma and urine