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have reported in healthy male smokers ( n = 21) compared to non-smokers ( n = 21) a significant increase in externalization of PS to the outer leaflet of the RBCs membrane, a hallmark of eryptosis, which was significantly correlated to the plasma level of CRP and GSH concentration in erythrocytes [440]

We thank Rufus Watson, Hiromi Matsuyama, and Nobue Sakanishi for providing updated information on COVID-19

If cold sensitivity persists beyond six months of stable weight or significantly impairs quality of life, discussing dose adjustment or alternative treatment strategies with healthcare providers is appropriate