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Description
Differentiation of monocytes to mature tissue macrophages is generally associated with a reduction of their microbicidal activity, partly due to a substantial decrease in oxygen-dependent mechanisms of toxicity leading to a much lower level of respiratory burst and MPO function [167,168,169,170]

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[2] Signs and symptoms [edit] A reaction typically begins within 24 hours of exposure and peaks at 4872 hours after exposure
doi: 10.1016/j.intimp.2016.10.008