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Following SCI, lesion-adjacent microglia phagocytose cellular debris and secrete pro-inflammatory cytokines that recruit infiltrating immune cells into the spinal cord (SC) (Hakim et al., 2021

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10.1371/journal.pone.0043651 54 MicklinghoffJ

However, its mechanistic variability across models underscores the need for: (1) unified mechanistic studies, (2) advanced in vivo models, (3) early-phase clinical trials to evaluate human safety and efficacy