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Its metabolic disorders can lead to uncontrolled blood glucose levels, accelerating the deterioration of -cell function and leading to complications (Zhang and Lin, 2004) (Figure 2)

The PDCs discussed here are categorized by the bond between the drug and the linker

Furthermore, E2 supplementation has been found to mitigate the elevated oxidative stress levels induced by CIH significantly and to enhance the activity of antioxidant enzymes, such as zinc/manganese superoxide dismutase and glutathione peroxidase, which protect against oxidative stress-related damage (14, 44, 64, 65)