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Commercial development was discontinued in 2007 after the Phase IIb trial failed to meet its primary endpoint

This enzyme is important in glutathione metabolism, since, by breaking the gamma-glutamyl moiety of GSH, GSSG or GSH conjugates, the free glutamate is rapidly transferred to another external amino acid that originates a gamma-glutamyl-amino acid and the dipeptide cysteine-glycine [49]

Similarly, Lactobacillus plantarum HNU082 enriches Bifidobacterium pseudolongum and increases short-chain fatty acids (SCFAs), which strengthens the epithelial barrier and suppresses NF-B signaling

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