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IL-6 levels can rise up to 100-fold during prolonged activity and play key roles in hepatic glucose output, adipose tissue lipolysis, and anti-inflammatory signaling (76, 77)

This is supported by metabolomic profiling studies that have identified complex lipid species and amino acid analogues associated with the response to weight loss interventions

Osteonecrosis of the femoral head was significantly alleviated after intraperitoneal injection of tanshinone I
