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Several mechanisms may explain reduced effectiveness over time
Apart from its action on insulin sensitivity, hyperglycemia also exerts a direct negative effect on beta-cell function (glucotoxicity)
Following this, the mice were sedated and examined using a small animal imaging device (NightOWL LB 983 IN VIVO) at 1, 2, 8, 12, and 24 h after injection
The absolute lack of insulin, due to destruction of the insulin producing pancreatic -cells, is the particular disorder in type 1 diabetes
