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Murine models treating elastase generate COPD-like mucus obstruction from goblet cell hyperplasia, inflammatory responses, and emphysema (Fernndez-Blanco et al., 2018)

One important activator of production of NO in the endothelium is shear stress (43, 163)

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Although the precision mechanism remains obscure, several pathways are involved in proteasome inhibitor-induced tumor suppression
