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The interaction with eNOS and COX2 gene expression, and counteraction of the aggravation effect of the NOS-blocker, L-NAME [38], might suggest that NO system function might be accordingly recovered
In CD specifically, protein-based therapeutics targeting TNF have been shown to facilitate mucosal healing by endoscopy, reducing the need for surgical intervention ( For CD patients, inducing and maintaining a state of deep remission is the treatment goal
K., Goldstein, D., Pirola, R
