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In their studies, output results from pathway analysis, which are the -log10 ( p -value), and the impact factor (estimated as the sum of the importance measures of all metabolites in the pathway) were used as k descriptors (i.e., coordinates) of the metabolic pathway outcome (Moreno-Torres et al., 2021) (Figure 6)

The identified metabolites included amino acids and derivatives, fatty acids, lipid mediators, excretion metabolites, bile acids, organic acid and purine/pyrimidine metabolites

Three AdoMet-dependent lipid methyltransferases are known to exist, and lipid methylation has been implicated in the conversion of zymosterol to fecosterol within the ergosterol biosynthesis pathway which is necessary for accurate endocytosis, cell polarization, cell fusion, and cell wall assembly [7678]

Micronuclei induced by modulators of methylation: analogs of 5-azacytidine