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Kong P, Christia P, Frangogiannis NG

Collectively, these findings indicate that disruption of the glucagon receptor not only modifies the gene expression profile of cells but also alters the pancreatic islet microenvironment

Wu H, Esteve E, Tremaroli V, Khan MT, Caesar R, Manneras-Holm L, Sthlman M, Olsson LM, Serino M, Planas-Flix M, Xifra G, Mercader JM, Torrents D, Burcelin R, Ricart W, Perkins R, Fernndez-Real JM, Bckhed F (2017) Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

However, degradation rates can be increased by temperature changes occurring during transportation