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A putative scenario might be that Igf-1 keeps progenitors in a healthy or fit state in which they are ready for further cell divisions, for which Fgf-2 or Egf are the instructive cues

Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin

Oncogene 2018;37:191125
