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Description
It is the time taken for half of the administered dose of a drug to be eliminated from the body

Following IV administration of 2 mg/kg in bile duct cannulated (BDC) rats, urinary and biliary excretions of unchanged parent drug were 65 and 0.8% of dose, respectively, suggesting that urinary excretion is a major elimination route for GS-441524 in rats

Conversely, when translucency diminishes, These factors are often combined

In conclusion, despite being well tolerated in the used regimen, oral N-acetylcysteine was not effective in the treatment of melasma
