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Saparov, S

64, e0138719

[00027] "Optional" or "optionally" as used herein means that the subsequently described event or circumstance can or cannot occur, and that the description includes instances where the event or circumstance occurs and instances where it does not

FIGURE 1 2.1 The inhibition of the system Xc -glutathione (GSH)glutathione peroxidase 4 (GPX4) axis The system Xc is a heterodimeric antiporter on the plasma membrane, which is composed of solute carrier family seven-member 11 (SLC7A11/xCT) and solute carrier family three member 2 (SLC3A2) with a disulfide bond ( functions to exchange extracellular cystine and intracellular glutamate at a ratio of 1:1 ( 2 O 2 to water ( GSH-GPX4 axis leads to the accumulation of lethal lipid peroxides and the occurrence of ferroptosis