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Description
The ALS Functional Rating Scale-Revised (ALSFRS-R) is a scale that determines the progression and severity of ALS patients and is widely used in clinical trials (Rooney et al., 2017)

The pHrate profile of the conversion of reduced SetCys peptide 2 into cysteinyl peptide 3 shows a maximum at pH 6.0 0.04 and two inflexion points at pH 4.8 and 7.3, which likely correspond to the pK a s of the SetCys selenol and ammonium groups, respectively

Novo Nordisk developed it as a long-acting version of the naturally occurring hormone, engineered with specific amino acid substitutions that extend its duration of action from minutes to days

Neurotrophic signaling by membrane electrical activity in spiral ganglion neurons
