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Published articles that addressed the review objective were discussed and reviewed, and selected papers were supplemented by the clinical experience of the panel

Ethical Approval This study was approved by the Institutional Animal Care and Use Committee of Washington State University and conducted in accordance with National Institutes of Healths Guidelines for the Care and Use of Laboratory Animals

KEY POINTS Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and their clearance by antioxidants

T cells have recently attracted substantial interest as effector cells in cell-based cancer immunotherapy due to their potent capacity to kill a variety of different cancer cell types in the absence of HLA restriction