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It utilized inducible cell lines for initial validation, corroborated relevance in ex vivo and knockout models, and finally interrogated the underlying mechanisms using brain slice electrophysiology and pharmacology
Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
Hepatocellular carcinoma (HCC) Sorafenib is widely used in the treatment of advanced HCC, and inducing ferroptosis of HCC cells is an important mechanism for the biological effects of sorafenib
