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8 When APAP is administered at therapeutic doses under normal physiological conditions, the remaining 510% of the drug is metabolized in hepatocytes by cytochrome P450 enzymes such as CYP2E1 and CYP1A2 through phase I enzymatic reactions, resulting in the generation of the toxic reactive metabolite NAPQI (Fig

For the cardiotoxic effects of sorafenib (SOR), the upregulation of ATF4 expression attenuated cardiomyocyte ferroptosis ( Increased ATF6 expression induced by androgen deprivation in prostate cancer renders prostate cancer (Pca) cells resistant to ferroptosis

In comparison, CM6 gave the fragment ions at m/z 306 and 194 (Supplementary Information, Figure S2), indicating that both hydroxylation events took place on the phenoxyethyl-5-ethyltriazolone propyl motif of the molecule, one presumably being on the 5-ethyl side chain, one on another position

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