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In the liver and other tissues, glutathione binds to certain toxins and waste products

Hence, the combination of multiple factors including genotype, mode of delivery, early antibiotic therapy, diet composition, lifestyle, social interactions and environmental exposure to various xenobiotics shape the gut microbiota to make every individual microbially unique

Although the overall evidence suggests that at least a subset of patients with ME/CFS exhibit reduced cortisol output, some cohorts show only modest reductions, preserved cortisol output, or context-dependent abnormalities rather than stable hypocortisolism, indicating that HPA-axis dysfunction in ME/CFS is likely heterogeneous and multifactorial rather than a specific or uniform neuroendocrine abnormality (Tomas et al., 2013

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