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486 Similarly, in CSCs, metformin, an inhibitor of mitochondrial complex I, when combined with JQ-1, a BET inhibitor, or LY294002, a PI3K inhibitor, has shown potential in preclinical models by simultaneously impairing mitochondrial respiration and indirectly suppressing glycolysis
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doi: 10.1056/NEJMc2107725 179 RoccatelloDSciasciaSRossiDFenoglioR
