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The significance of IDH1 and IDH2 produced NADPH can be made clear by pointing out that cells with low level IDH1 and IDH2 expression are more sensitive to oxidative stress than cells with higher levels of expression of these two enzymes
-Glutamylcysteine Synthetase (GCS/GCLC) is the rate-limiting, feedback-inhibited enzyme in GSH synthesis
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Administration of the Nrf2 inducer dimethyl fumarate in MS models showed reduced levels of oxidative stress and preservation of nerve fiber myelination, which is lost in Nrf2 / mice [488, 489]
