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The difference is that RA is an autoimmune disease that causes joint inflammation and damage to the joints

2022) engineered Escherichia coli Nissle 1917 to stably express catalase and SOD, enabling active scavenging of intestinal reactive oxygen species, thereby more effectively repairing the epithelial barrier and modulating the microbiota

doi: 10.15430/JCP.2020.25.3.127 319 RoeserJCLeachSDMcAllisterF

The study also found that hydrogen-rich water alleviates intestinal oxidative stress by upregulating the expression of SIRT1, Nrf2, and HO-1, thus activating the SIRT1/Nrf2/HO-1 signaling pathway, which further improves constipation