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found that adipocyte-derived leptin activated JAK-STAT3-CPT1B to drive FAO in breast CSCs (BCSCs), leading to paclitaxel resistance [101]

Immunotherapies and cell therapies associated with senolytic activity Regulation of the immune system The senescent process directly impacts the cells in which this biological mechanism is activated but also the surrounding cells through the SASP or specific proteins expression at the plasma membrane

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We demonstrate prolonged plasma half-life and improved biodistribution for full-length IgG antibodies and Fc-based formats in human FcRn-expressing mice, allowing for both invasive and non-invasive delivery