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It has been proposed that ROS can affect OA articular chondrocytes through LDHA-mediated effects, and therefore reducing ROS formation function by inhibiting LDHA is an effective way to inhibit inflammation (100)

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Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca 2+ in the endoplasmic reticulum