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Description
Mutations in LRRK2 impair its function and disrupt the formation of aggressive aggregates (aggresomes) that normally facilitate the autophagic clearance of protein aggregates (Stefanis et al., 2019)

Parkin is an E3 ubiquitin ligase which attaches ubiquitin to damaged mitochondria to mark them for removal

"Current Status of the -Glutamyl Cycle"

The result is sustained growth hormone elevation with less frequent dosing
