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2 Methods 2.1 Materials All chemicals and reagents utilized in this study were purchased from commercial sources without further purification

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Pagnotta S, Tramutola A, Barone E, Di Domenico F, Pittal V, Salerno L, Folgiero V, Caforio M, Locatelli F, Petrini S, et al

Concurrently, exercise is recognized for its ability to stimulate the release of neurotrophic factors [proteins that support the growth, survival, and differentiation of neurons, as well as promote neurogenesis, synaptic plasticity, and repair of the nervous system, playing a critical role in maintaining neural health and function], like BDNF and insulin-like growth factor 1 (IGF-1), which enhance neural connectivity and reduce the risk of cognitive decline [7]

Later, similar observations were made in gastrointestinal tumors, neuroblastomas, renal tumors, thyroid tumors, and testicular tumors 125,126