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Following administration in phase 1 and phase 2 clinical studies[16]: Time to maximum concentration (Tmax) occurs 12 to 72 hours after subcutaneous injection Dose-proportional pharmacokinetics observed across the therapeutic dose range (1 mg to 12 mg) Steady-state concentrations achieved after approximately 4 weeks of weekly dosing The fatty diacid conjugation enables albumin binding, extending circulation time Systemic exposure increases proportionally with dose escalation Distribution studies indicate widespread tissue distribution following absorption, with concentrations sufficient to engage receptor systems in metabolically relevant tissues including adipose tissue, liver, pancreas, and central nervous system regions involved in appetite regulation

doi: 10.1146/annurev.bi.55.070186.002235

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10.3389/fmolb.2022.1037941 [DOI] [PMC free article] [PubMed] [Google Scholar] McGee TP, Houston CM, & Brickley SG (2013)