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Clinical significance is associated with the IDH1 and IDH2 genes as there has been a close association made between mutations in these two genes and the development of certain forms of cancer, specifically gliomas of the brain

In addition, evaluating inhibitory tonus as a measure of repressed plasticity in the post-injured brain, concomitant changes in the excitatory input may occur, making it difficult to estimate changes in the overall excitatory/inhibitory balance of the neural circuits undergoing rearrangement

Therefore, CLC protein and eosinophil lysophospholipases are distinct proteins.93 Lastly, through its lectin-like domains, CLC protein may bind carbohydrates expressed on microorganisms or biological molecules, such as IgE or laminin.94 Many enzymes, in addition to EPO and the RNases (EDN and ECP), have been identified in human eosinophils, granules, and membranes (see Fig

doi: 10.1016/j.mce.2008.10.038