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B12 deficiency often goes hand in hand with a folate deficiency, says Kozlowski

The logic is that local administration creates higher peptide concentrations at the relevant tissue

There are a range of perturbations that result in the loss of proteostasis, including genetic mutations that alter amino acid sequences, errors during protein synthesis and post-translational modifications (PTMs), dysfunction of the molecular chaperones responsible for assisting protein folding, and various cellular stresses, such as heat shock, oxidative stress, and nutrient deprivation

Following fermentation, milk kefir undergoes ripening process where it is stored in refrigerated conditions for 8 to 24 h for a more viscous, tangy and slight effervescence final product (Laureys et al., 2018)
