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Glutathione exists in two primary forms: the reduced form (GSH), characterized by a free sulfhydryl group (-SH) on its cysteine residue, and the oxidized form, glutathione disulfide (GSSG), which is formed when two GSH molecules are linked via a disulfide bond between their cysteine residues during redox reactions

Studies have shown that BTZ can sensitize peripheral sensory nerve fibers, resulting in overactivity of WDR neurons and subsequent abnormal pain or nociceptive hypersensitivity (Stockstill et al., 2018

A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)

Although comprehensive mechanistic studies and clinical research on the combination of CDK4/6 inhibitors and anti-metabolic drugs are still limited, the combination of CDK4/6 inhibition with metabolic blockade holds great potential as an effective treatment option for patients in the future