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Oncotarget (2017) 8(5):898091

Nadeem A, Siddiqui N, AlHarbi NO, AlHarbi MM, Ahmad SF

Kliniki podaci kod ljudi veoma su ogranieni, a ne postoje dovoljne visokokvalitetne kontrolisane studije na osnovu kojih bi se mogle izvoditi pouzdane tvrdnje o sigurnosti ili djelotvornosti kod ljudi.Rezultate preklinikih istraivanja zato treba tumaiti iskljuivo u okviru koritenog eksperimentalnog modela

Loading Dose When the time to reach steady state is appreciable, as it is for drugs with long half-lives, it may be desirable to administer a loading dose that promptly raises the concentration of drug in plasma to the target concentration