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It was approved in 2018 for the treatment of X-linked hypophosphatemia and acts by blocking the function of fibroblast growth factor 23 (FGF23), increasing renal tubular phosphate reabsorption and normalizing serum phosphate levels [127]

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In practice, this had allowed compounding pharmacies and wellness clinics to market and dispense these substances without the clinical trial data the FDA requires of approved drugs