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Complexed CRP was previously shown to be an effective activator of the complement through C1q binding, and it may modulate pathophysiologic actions mediated via cryoglobulins in vivo since a previous case report described the formation of a complex between a monoclonal IgA with cryolabile properties and CRP

Tritsch T, Shoja MM, Schleffer A, Tubbs RS (2024)

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