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Psychoneuroendocrinology 119 , 104754 (2020)

High Loading Doses A loading dose of creatine involves taking between 20-25 grams per day for five to seven days to saturate muscle stores
This is important because muscle tissue is metabolically active and helps you maintain a higher metabolic rate

As glycine is one of the substrates for GSH synthesis, increased serine/glycine metabolism resulted in the accumulation of NAPDH/GSH, promoting the elimination of ROS
