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[Abstract]2026 May 27:10.1158/0008-5472.CAN-25-5172

Increased BBB permeability permits the entry of inflammatory cytokines, LPS, and other neurotoxic chemicals that can induce or worsen neuroinflammatory responses, further affecting brain function

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By blocking downstream pathways such as the NLRP3/caspase-1/IL-1 axis, PD symptoms may occur less frequently, suggesting a novel avenue for prevention and treatment