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It has been demonstrated that schisandrin B stimulate the expression of Hsp70 in normal cells [95,96,97,98,99,100,101], which is associated with the enhancement of mitochondrial glutathione status [95,97,100,101,102,103], antioxidant activity [59,96,104,105,106,107,108,109], ATP generation [110], mitigation of age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, enhancement in cognitive functions and an increase in the survival of aging in rodents [56,97,112]

Non-motor symptoms have detrimental effects on both patient life quality and caregiver experiences [14,15]

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