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NAD + (nicotinamide adenine dinucleotide) What it is: NAD is a coenzyme naturally present in cells

It is evident from previous studies that oxidative stress and mitochondrial dysfunction are involved in the pathophysiology of many metabolic disease states such as insulin resistance, obesity diabetes, and many cardiovascular and neurodegenerative diseases [101-112]

Harraz MM, Dawson TM, Dawson VL

We have previously established an experimental system based on human primary fibroblasts undergoing mild and progressive ER stress upon starvation for glucose and serum (GS starvation) (Michael et al, 2023), and showed that up-regulated ATF4 and IRE1a drive the UPR and a cytokine and chemokine response (Michael et al, 2023)